Epidemiology of CLL
Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the Western world, accounting for up to 35% of all leukemias and 1.3% of all cancers1,2
US Statistics from the SEER database.*
|Median Age at Diagnosis3||Incidence3||Prevalence3||Mortality3||5-Year Survival Rate3|
|Median Age at Diagnosis3|
|5-Year Survival Rate3|
*US Statistics from the SEER database collected 2009-2015 and last updated in 2019.
How CLL is diagnosed
CLL often presents without symptoms and is diagnosed incidentally through blood work4,5
The diagnosis of CLL requires ≥5 x 109/L B lymphocytes in the peripheral blood, sustained for ≥3 months
Clonality of B cells should be confirmed by flow cytometry
Symptoms usually develop slowly
Symptoms may include6
Unexplained weight loss or early satiety
Hyperhidrosis, night sweats
Infections, especially recurring infections
CLL=chronic lymphocytic leukemia, SEER=Surveillance, Epidemiology, and End Results Program.
Review the two main systems—Rai and Binet—for staging CLL
References: 1. Strati P, Jain N, O'Brien S. Chronic lymphocytic leukemia: diagnosis and treatment. Mayo Clin Proc. 2018;93(5):651-664. 2. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2018. CA Cancer J Clin. 2018;68(1):7-30. 3. National Institutes of Health, National Cancer Institute, Surveillance, Epidemiology, and End Results Program. SEER Cancer Stat Facts: Leukemia - Chronic Lymphocytic Leukemia (CLL). https://seer.cancer.gov/statfacts/html/clyl.html. Accessed May 12, 2020. 4. American Cancer Society, CLL, Early Detection, Diagnosis and Staging/Diagnosis. https://www.cancer.org/cancer/chronic-lymphocytic-leukemia/detection-diagnosis-staging/how-diagnosed.html. Accessed May 12, 2020. 5. Hallek M, Cheson BD, Catovsky D, et al. iwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLL. Blood. 2018;131(25):2745-2760. 6. American Cancer Society, CLL, Early Detection, Diagnosis and Staging/Signs & Symptoms. https://www.cancer.org/cancer/chronic-lymphocytic-leukemia/detection-diagnosis-staging/signs-symptoms.html. Accessed May 12, 2020.