Epidemiology of CLL

Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the Western world, accounting for up to 35% of all leukemias and 1.3% of all cancers1,2

US Statistics from the SEER database.*

Median Age at Diagnosis3 Incidence3 Prevalence3 Mortality3 5-Year Survival Rate3
70 years 21,040 186,422 4,060 86.1%
Median Age at Diagnosis3
70 years
Incidence3
21,040
Prevalence3
186,422
Mortality3
4,060
5-Year Survival Rate3
86.1%

*US Statistics from the SEER database collected 2009-2015 and last updated in 2019.

How CLL is diagnosed

CLL often presents without symptoms and is diagnosed incidentally through blood work4,5
  • The diagnosis of CLL requires ≥5 x 109/L B lymphocytes in the peripheral blood, sustained for ≥3 months

  • Clonality of B cells should be confirmed by flow cytometry

  • Symptoms usually develop slowly

Symptoms may include6
  • Fatigue

  • Unexplained weight loss or early satiety

  • Pyrexia

  • Lymphadenopathy

  • Organomegaly

  • Hyperhidrosis, night sweats

  • Infections, especially recurring infections

  • Abnormal bruising

CLL=chronic lymphocytic leukemia, SEER=Surveillance, Epidemiology, and End Results Program.

Staging CLL

Review the two main systems—Rai and Binet—for staging CLL

Learn More

References: 1. Strati P, Jain N, O'Brien S. Chronic lymphocytic leukemia: diagnosis and treatment. Mayo Clin Proc. 2018;93(5):651-664. 2. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2018. CA Cancer J Clin. 2018;68(1):7-30. 3. National Institutes of Health, National Cancer Institute, Surveillance, Epidemiology, and End Results Program. SEER Cancer Stat Facts: Leukemia - Chronic Lymphocytic Leukemia (CLL). https://seer.cancer.gov/statfacts/html/clyl.html. Accessed May 12, 2020. 4. American Cancer Society, CLL, Early Detection, Diagnosis and Staging/Diagnosis.  https://www.cancer.org/cancer/chronic-lymphocytic-leukemia/detection-diagnosis-staging/how-diagnosed.html. Accessed May 12, 2020. 5. Hallek M, Cheson BD, Catovsky D, et al. iwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLL. Blood. 2018;131(25):2745-2760. 6. American Cancer Society, CLL, Early Detection, Diagnosis and Staging/Signs & Symptoms. https://www.cancer.org/cancer/chronic-lymphocytic-leukemia/detection-diagnosis-staging/signs-symptoms.html. Accessed May 12, 2020.

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